Let someone know where you're running.Before you head out for your run, make sure you let someone else know where you're running. Also tell them approximately how long you'll be running for.
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Try some self-talk.If you're running alone and struggling, give yourself a pep talk. Tell yourself that you're not physically tired -- you're just mentally fatigued and you can push through it. Say to yourself things like, "I'll have some water in five minutes -- that will make me feel better." You may want to keep repeating a mantra, like, "Think strong! Be strong!" If you're doing your longest run ever, remind yourself how proud you'll feel when you're finished.
More: Mental Strategies for Long Runs
Carry identification.Put your driver's license and your medical insurance card (in case you get injured) in your pocket or wear an ID tag on your shoe. If you're wearing an ID tag or bracelet, make sure it has an emergency contact number on it. Whenever possible, try to run with your cell phone, and save your ICE (In Case of Emergency) numbers.
Mix it up with a random interval workout.To beat boredom when running, try doing a fun interval workout. Pick a landmark in the distance, such as a tree or a stop sign, and pick up the pace until you get to it. After you recover for a minute or two, choose another landmark and speed up again.
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Be visible.It's easy to miss a single runner on the road, so make sure you're visible. If you're running in the early morning or at night, even at dusk, wear white, yellow, or orange clothes. Also, make sure you have reflective gear on. Although some items (running shoes, jackets) already have reflective pieces on them, it doesn't hurt to add more.
More: Reflective Gear for Runners